Comparative GC Analysis, Bronchodilator Effect and the Detailed Mechanism of Their Main Component; Cinnamaldehyde of Three Cinnamon Species

Cinnamon is one of the most commonly used spices worldwide. In some Arab countries, cinnamon with other ingredients to relieve bronchospasm and treatment airways-related disorders. current study, GC, GC-MS tracheal relaxant effect comparison were performed using three available types in Saudi Arabia, Cinnamomum verum (Ceylon cinnamon), C. cassia (Chinese cinnamon) loureiroi (Vietnamese cinnamon). The essential oil was potent relaxation guinea pig isolated muscles against carbachol (CCh, 1 uM)-evoked at concentration range from 0.03 3 mg/mL followed by bureiroi 5 mg/mL; whereas, least oil. Cinnamaldehyde (1), as main component oils induced complete low K+ (25 mM)-evoked contractions, mild on contractions evoked high (80 mM). Pre-incubation tissues glibenclamide (10 mM) significantly opposed cinnamaldehyde. standard drug, cromakalim also inserted glibenclamide-sensitive inhibition without relaxing K+. These results indicate that cinnamaldehyde acts predominantly ATP-specific channel opening weak Ca++ antagonistic effects. obtained justify medicinal value respiratory